Table 3. Multivariate associations of the SNPs in ANRIL exons with the risk of MI.
| Type | Controls (n= 646) | Cases (n= 286) | OR (95% CI) a | P a | |
|---|---|---|---|---|---|
| No. (%) | No. (%) | ||||
| rs10965215 | |||||
| Additive | A | 921 (71.3) | 386 (67.5) | 1.00 | - |
| G | 371 (28.7) | 186 (32.5) | 1.37 (1.05-1.78) | 0.020 b | |
| Genotype | AA | 319 (49.4) | 127 (44.4) | 1.00 | - |
| AG | 283 (43.8) | 132 (46.2) | 1.40 (0.99-1.97) | 0.061 | |
| GG | 44 (6.8) | 27 (9.4) | 1.81 (0.97-3.40) | 0.064 | |
| Dominant | AA | 319 (49.4) | 127 (44.4) | 1.00 | - |
| AG+GG | 327 (50.6) | 159 (55.6) | 1.45 (1.04-2.03) | 0.030 | |
| Recessive | AG+AA | 602 (93.2) | 259 (90.6) | 1.00 | - |
| GG | 44 (6.8) | 27 (9.4) | 1.53 (0.84-2.80) | 0.164 | |
| rs76521274 | |||||
| Additive | C | 197 (15.2) | 88 (15.4) | 1.00 | - |
| T | 1095 (84.8) | 484 (84.6) | 1.07 (0.77-1.49) | 0.682 | |
| Genotype | CC | 11 (1.7) | 6 (2.1) | 1.00 | - |
| TC | 175 (27.1) | 76 (26.6) | 1.23 (0.33-4.62) | 0.764 | |
| TT | 460 (71.2) | 204 (71.3) | 1.29 (0.35-4.76) | 0.701 | |
| Dominant | CT+CC | 186 (28.8) | 82 (28.7) | 1.00 | - |
| TT | 460 (71.2) | 204 (71.3) | 1.07 (0.74-1.53) | 0.730 | |
| Recessive | CC | 11 (1.7) | 6 (2.1) | 1.00 | - |
| CT+TT | 635 (98.3) | 280 (97.9) | 1.27 (0.35-4.67) | 0.717 | |
| rs76184305 | |||||
| Additive | T | 191 (14.8) | 87 (15.2) | 1.00 | - |
| C | 1101 (85.2) | 485 (84.8) | 0.98 (0.70-1.38) | 0.916 | |
| Genotype | TT | 10 (1.5) | 6 (2.1) | 1.00 | - |
| CT | 171 (26.5) | 75 (26.2) | 0.81 (0.20-3.25) | 0.768 | |
| CC | 465 (72.0) | 205 (71.7) | 0.85 (0.22-3.32) | 0.813 | |
| Dominant | CT+TT | 181 (28.0) | 81 (28.3) | 1.00 | - |
| CC | 465 (72.0) | 205 (71.7) | 1.03 (0.72-1.49) | 0.857 | |
| Recessive | CT+CC | 636 (98.5) | 280 (97.9) | 1.00 | - |
| TT | 10 (1.0) | 6 (2.1) | 1.19 (0.31-4.66) | 0.798 | |
| rs10738605 | |||||
| Additive | G | 943 (73.0) | 396 (69.2) | 1.00 | - |
| C | 349 (27.0) | 176 (30.8) | 1.38 (1.06-1.80) | 0.019 | |
| Genotype | GG | 337 (52.2) | 131 (45.8) | 1.00 | - |
| GC | 269 (41.6) | 134 (46.9) | 1.59 (1.13-2.26) | 0.008 | |
| CC | 40 (6.2) | 21 (7.3) | 1.47 (0.75-2.88) | 0.266 | |
| Dominant | GG | 337 (52.2) | 131 (45.8) | 1.00 | - |
| GC+CC | 309 (47.8) | 155 (54.2) | 1.58 (1.13-2.20) | 0.008 | |
| Recessive | GC+GG | 606 (93.8) | 265 (92.7) | 1.00 | - |
| CC | 40 (6.2) | 21 (7.3) | 1.17 (0.61-2.24) | 0.635 | |
| rs78766516 | |||||
| Additive | G | 1103 (85.4) | 500 (87.4) | 1.00 | - |
| A | 189 (14.6) | 72 (12.6) | 0.82 (0.57-1.16) | 0.261 | |
| Genotype | GG | 467 (72.3) | 217 (75.9) | 1.00 | - |
| AG | 169 (26.2) | 66 (23.1) | 0.83 (0.57-1.23) | 0.354 | |
| AA | 10 (1.5) | 3 (1.0) | 0.56 (0.12-2.65) | 0.466 | |
| Dominant | AG+GG | 636 (98.5) | 283 (99.0) | 1.00 | - |
| AA | 10 (1.5) | 3 (1.0) | 0.59 (0.13-2.78) | 0.503 | |
| Recessive | GG | 467 (72.3) | 217 (75.9) | 1.00 | - |
| AG+AA | 179 (27.7) | 69 (24.1) | 0.82 (0.56-1.20) | 0.299 | |
Abbreviations: SNP, single nucleotide polymorphism; MI, myocardial infarction; OR, odds ratio; CI, confidence interval.
a Adjusted for age, sex, smoking, drinking, hypertension, diabetes, hyperlipidemia.
b P values under 0.05 were indicated in bold font.