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. 2017 Feb 7;8(8):12649–12663. doi: 10.18632/oncotarget.15172

Figure 3. Dvl2 increases synovial apoptosis and reduces the secretion of inflammatory cytokines in the knee joints of CIA rats.

Figure 3

A. Synovial apoptosis in the knee joints was analyzed by TUNEL staining. B. Quantitative evaluation of TUNEL-positive synovial cells (n = 5/group). C. The level of intra-articular inflammatory cytokines was analyzed by ELISA (n = 10/group). *p < 0.05, **p < 0.01; CIA, collagen-induced arthritis; Normal, healthy rats without CIA; Dvl2, the knee joints of CIA rats injected with lentivirus-Dvl2; Control, the knee joints of CIA rats injected with lentivirus-control. Scale bars: 100 μm.