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. 2017 Feb 7;8(8):12649–12663. doi: 10.18632/oncotarget.15172

Figure 4. Overexpression of Dvl2 increases RA-FLS apoptosis by reducing expression of NF-κB-dependent anti-apoptotic genes.

Figure 4

A. The downregulated high-ranked pathways upon Dvl2 overexpression in RA-FLSs B. The viability of Dvl2-overexpressing RA-FLSs was assessed via CCK-8 assays at the indicated time points. C. RA-FLS apoptosis was analyzed by flow cytometry. D. The percentages of apoptotic cells are displayed in the histogram. E. Cluster diagram of the NF-κB signaling pathway when Dvl2 was overexpressed in RA-FLSs. Red indicates high relative expression, and green indicates low relative expression. F. The expression levels of NF-κB-dependent anti-apoptotic genes were validated by RT-PCR. *p < 0.05, **p < 0.01, NSp > 0.05; Dvl2, RA-FLSs infected with lentivirus-Dvl2; Control, RA-FLSs infected with lentivirus-control.