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. 2017 Feb 7;8(8):12649–12663. doi: 10.18632/oncotarget.15172

Figure 5. Overexpression of Dvl2 inhibits TNF-α-induced inflammatory cytokine secretion by RA-FLSs.

Figure 5

A. Cluster diagram of the TNF signaling pathway when Dvl2 was overexpressed in RA-FLSs. Red indicates high relative expression, and green indicates low relative expression. B. Cell supernatant levels of IL-1β, IL-6, and IL-8 in RA-FLSs were analyzed by ELISA. C. The mRNA expression levels of IL-1β, IL-6, and IL-8 were validated by RT-PCR. NSp > 0.05, *p < 0.05, **p < 0.01; Dvl2, RA-FLSs infected with lentivirus-Dvl2; Control, RA-FLSs infected with lentivirus-control.