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. 2017 Jan 16;8(8):13003–13014. doi: 10.18632/oncotarget.14674

Table 1. GO profiling identified in 10 main biological behaviors after Talin-1 silencing.

GO_term (ID) P-value enrich_factor Nr. Genes (upregulate/downregulate) up-regulated geneID (mRNA) down-regulated geneID (mRNA)
membrane repolarization 1.74E-06 7.611999094 6 (2/4) KCNE3 ([NM_005472]), GJA1 ([NM_000165]), KCNQ1 ([NM_000218]),
(GO:0086009) CACNA1D ([NM_000720]) AKAP6 ([NM_004274]), CAV3 ([NM_001234])
cell growth 5.37E-06 2.282109371 24 (7/17) CGREF1 ([NM_006569]), SLC44A4 ([NM_025257]), EDN1 ([NM_001955]), IGFBP5 ([NM_000599]),
(GO:0016049) RIMS1 ([NM_014989]), TRIM40 ([NM_138700]), CYR61 ([NM_001554]), PDGFB ([NM_002608]),
OMG ([NM_002544]), SLIT2 ([NM_004787]) CTGF ([NM_001901]), IGFBP3 ([NM_001013398])
ion transport 2.50E-08 1.792892772 29 (11/18) KCNE3 ([NM_005472]), SLCO1B3 ([NM_019844]), CLIC3 ([NM_004669]), CTGF ([NM_001901]),
(GO:0006811) ALB ([NM_000477]), TESC ([NM_017899]) CAV3 ([NM_001234]), AQP1 ([NM_198098]),
PTGS2 ([NM_000963]), CA9 ([NM_001216]),
extracellular space 2.73E-07 1.750628487 47 (14/33) MUC5B ([NM_002458]), MMEL1 ([NM_033467]), EDN1 ([NM_001955]), WISP2 ([NM_003881]),
(GO:0005615) SLIT2 ([NM_004787]), SPX ([NM_030572]), KRT34 ([NM_021013]), MUC17 ([NM_001040105]),
PDGFC ([NM_016205]), FAM184A ([NM_024581]) KLHL34 ([NM_153270]), VTN ([NM_000638])
cell adhesion 6.06E-07 1.729052887 28 (9/19) VCAM1 ([NM_001078]), ADAM22 ([NM_021721]), MUC1 ([NM_002456]), SLAMF7 ([NM_021181]),
(GO:0007155) RGCC ([NM_014059]), CGREF1 ([NM_006569]), WISP1 ([NM_003882]), VTN ([NM_000638]),
GLI2 ([NM_005270]), FGB ([NM_005141])
transporter activity 8.73E-06 1.693649687 25 (10/15) SLCO1B3 ([NM_019844]), ANO5 ([NM_213599]), PTGDS ([NM_000954]), CLIC3 ([NM_004669]),
(GO:0005215) SLC26A9 ([NM_052934]), KCNE3 ([NM_005472]), PDE2A ([NM_002599]), SLC2A14 ([NM_001286233]),
SLC39A8 ([NM_022154]), SCN9A ([NM_002977]) ANKH ([NM_054027]), SLC2A5 ([NM_003039])
transmembrane transport 4.51E-06 1.689015481 29 (12/17) SLCO1B3 ([NM_019844]), ANO5 ([NM_213599]), CLIC3 ([NM_004669]), PDE2A ([NM_002599]),
(GO:0055085) ALB ([NM_000477]), SLC26A9 ([NM_052934]), CAV3 ([NM_001234]), EDN1 ([NM_001955]),
TESC ([NM_017899]), KCNE3 ([NM_005472]) SLC2A14 ([NM_001286233]), ANKH ([NM_054027])
regulation of multicellular organismal process 1.26E-07 1.564495121 58 (16/42) IFITM1 ([NM_003641]), SLIT2 ([NM_004787]), CYR61 ([NM_001554]), EDN1 ([NM_001955]),
(GO:0051239) SEMA4D ([NM_006378]), SPX ([NM_030572]), NR4A2 ([NM_006186]), ANKH ([NM_054027]),
TESC ([NM_017899]), ADM2 ([NM_024866]) EGR3 ([NM_004430]), GDNF ([NM_000514])
plasma membrane part 2.43E-08 1.551785285 52 (20/32) FUT1 ([NM_000148]), SLCO1B3 ([NM_019844]), CD247 ([NM_198053]), DTNA ([NM_001128175]),
(GO:0044459) TSPAN32 ([NM_139022]), CEACAM5 ([NM_004363]), PDE2A ([NM_002599]), CAV3 ([NM_001234]),
SLC26A9 ([NM_052934]), TESC ([NM_017899]) ANKH ([NM_054027]), DUOX2 ([NM_014080])
response to external stimulus 4.78E-07 1.52078304 57 (19/38) MATN2 ([NM_030583]), MUC5B ([NM_002458]), FGFBP1 ([NM_005130]), DUOX2 ([NM_014080]),
(GO:0009605) IFITM1 ([NM_003641]), SLIT2 ([NM_004787]), NR4A1 ([NM_002135]), VTN ([NM_000638]),
UNC5B ([NM_170744]), NPAS3 ([NM_022123]) TREM1 ([NM_018643]), FOSB ([NM_006732])