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. 2016 Dec 31;8(8):13085–13098. doi: 10.18632/oncotarget.14393

Figure 2. High-throughput drug screening for intractable lymphoma.

Figure 2

A. The scheme of the drug screening method is shown. Library compounds were added to lymphoma cells that were co-cultured with CAF on 96-well plates. After 48 h, the viability of the lymphoma cells was analyzed using an image analyzer. B. Results of the drug screening are shown. All compounds were plotted on a scattergram in which the relative viability of lymphoma cells and of CAF were indicated on the Y-axis and X-axis, respectively. Emetine is indicated as a red square. The gray line indicates a relative viability value of 0.5. C. The chemical structural formula of emetine is shown. D. Dose-dependent anti-lymphoma effects of emetine. The death of lymphoma cells from patient #1 (circles, solid line) and #2 (squares, dotted-line) that were co-cultured with CAF in the presence of various concentrations of emetine for 48 h is shown. Each point represents the mean value for three independent experiments. Error bars represent SEM.