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. 2017 Jan 14;8(8):13223–13239. doi: 10.18632/oncotarget.14656

Figure 7. PDE5 knockdown increases PARP1 activity in GBM cells.

Figure 7

A. sh-scr (PDE5+) or sh1-PDE5 (PDE5-) T98G cells were treated with increasing X-ray doses from 2 to 4 Gy and probed with anti-PAR and anti-PARP-1 antibodies. B. sh-scr or sh1-PDE5 T98G cells were exposed to X-rays at 4 Gy in the presence or absence (+/-) of the PARP1 inhibitor olaparib (1 μM). Total protein PARylation levels were assayed after 24 h. C. Schematic representation of cGMP signaling pathway promoting migration and DNA repair in GBM cells.