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. 2017 Jan 5;8(8):13357–13366. doi: 10.18632/oncotarget.14528

Figure 5. THUMPD1 promoted cancer cell invasion and migration via the AKT-GSK3β-Snail pathway.

Figure 5

THUMPD1 overexpression in MCF-7 and MDA-MB-468 cells upregulated Snail and downregulated E-cadherin, whereas THUMPD1 knockdown downregulated Snail and upregulated E-cadherin (A) p-AKT and its downstream target, p-GSK3β, were increased in THUMPD1-overexpressing MCF-7 and MDA-MD-468 cells, but decreased in THUMPD1-deficient MCF-7 and BT-549 cells (B) AKT inhibitor, LY294002 (10 μM), reversed the effects of THUMPD1 on p-AKT and p-GSK3β expression, decreasing Snail and increasing E-cadherin (C) and reducing THUMPD1-overexpressing MCF-7 cell invasion (D).