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. 2017 Jan 6;8(8):13375–13386. doi: 10.18632/oncotarget.14533

Figure 4. Interaction between DNA methylation and gene expression landscapes.

Figure 4

(A) Distribution of the DNA methylation test statistics (HPV-inactive vs. HPV-active) of the significant differently methylated CpGs. The majority of gene-associated and unclassified CpGs were hypomethylated in HPV-inactive tumors (negative test statistic), whereas promoter-associated CpGs were equally divided between hypermethylated (positive test statistic) and hypomethylated (negative test statistic). (B) Distribution of the gene expression test statistics (HPV-inactive vs. HPV-active) of the genes associated with significant differently methylated CpGs. Test statistics (and expression levels) of genes near gene-associated or unclassified CpGs were not correlated with CpG methylation levels, whereas test statistics (and expression levels) of genes near promoter-associated CpGs were inversely correlated with CpG methylation levels.