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. 2017 Jan 13;8(8):13703–13715. doi: 10.18632/oncotarget.14626

Figure 6. CTLA-4+BCCs-treated DCs inhibit the cytokine production in cocultur with CD4+/CD8+ T cells.

Figure 6

After different conditioned DCs (imDC, mDC, mDC+CTLA-4, mDC+231, mDC+231+Ab) cocultured with allogeneic CD4+ naïve T cells or CD8+ T cells for 5 days, the cell-free supernatants were harvested, and the production of IL-1β, IL-4, IL-10, IL-12p70, IL-17a, IFN-γ, and TNF-α was detected by the Bio-Plex Protein Array system. (A) and (B) represented the cytokine profile (IL-1β, IL-4, IL-6, IL-10, IFN-γ, and TNF-α) in the coculture system of naïve CD4+ T cells. (C) and (D) represented the cytokine (IL-1β, IL-6, IL-10, IFN-γ, and TNF-α) production in the coculture system of CD8+ T cells. The data are presented as mean ± SD of duplicate samples. *P < 0.05, **P < 0.01 and ***P < 0.001.