Table 2. Summary ORs and 95% CI of Let-7-KRAS rs712 G > T polymorphisms and cancer risk.
| N* | T vs. G | GT vs. GG | TT vs. GG | GT+TT vs. GG | TT vs. GG+GT | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | OR | 95% CI | P | I2(%) | OR | 95% CI | P | I2(%) | OR | 95% CI | P | I2(%) | OR | 95% CI | P | I2(%) | OR | 95% CI | P | I2(%) | |||||
| Total | 13 | 1.21 | 1.03-1.42 | 0.03 | 75.8 | 1.11 | 0.93-1.31 | 0.24 | 62.0 | 1.61 | 0.98-2.65 | 0.06 | 79.8 | 1.16 | 0.96-1.41 | 0.12 | 72.8 | 1.69 | 1.17-2.42 | 0.01 | 67.4 | ||||
| Sensitive analysis# | 12 | 1.30 | 1.20-1.41 | <0.01 | 33.7 | 1.18 | 1.07-1.31 | <0.01 | 0 | 2.07 | 1.65-2.59 | <0.01 | 24.8 | 1.27 | 1.15-1.41 | <0.01 | 3.2 | 1.96 | 1.57-2.44 | <0.01 | 14.8 | ||||
| Location | |||||||||||||||||||||||||
| Digestive system | 5 | 1.41 | 1.26-1.57 | <0.01 | 0 | 1.24 | 1.07-1.43 | <0.01 | 0 | 2.53 | 1.86-3.44 | <0.01 | 0 | 1.36 | 1.19-1.56 | <0.01 | 0 | 2.35 | 1.73-3.19 | <0.01 | 0 | ||||
| Head and neck | 3 | 1.20 | 0.86-1.67 | 0.29 | 70.6 | 1.09 | 0.79-1.50 | 0.61 | 49.8 | 1.65 | 0.82-3.32 | 0.16 | 52.7 | 1.16 | 0.81-1.67 | 0.42 | 64.2 | 1.58 | 0.86-2.92 | 0.14 | 40.1 | ||||
| Lung | 2 | 0.72 | 0.34-1.56 | 0.41 | 84.1 | 0.46 | 0.06-3.59 | 0.46 | 93. | 0.29 | 0.06-1.52 | 0.14 | 73.9 | 0.43 | 0.05-3.41 | 0.42 | 94.6 | 0.63 | 0.43-0.92 | 0.02 | 0 | ||||
| Cervical | 2 | 1.35 | 0.90-2.02 | 0.14 | 75.5 | 1.21 | 0.96-1.52 | 0.11 | 0 | 2.20 | 0.70-6.94 | 0.18 | 72.0 | 1.32 | 0.93-1.88 | 0.12 | 54.8 | 2.03 | 0.70-5.90 | 0.19 | 68.4 | ||||
| Breast | 1 | 1.06 | 0.76-1.48 | 0.73 | NA | 1.02 | 0.68-1.52 | 0.92 | NA | 1.28 | 0.45-3.60 | 0.65 | NA | 1.04 | 0.71-1.54 | 0.83 | NA | 1.27 | 0.45-3.55 | 0.65 | NA | ||||
| Design | |||||||||||||||||||||||||
| HB | 12 | 1.20 | 1.00-1.43 | 0.05 | 77.6 | 1.09 | 0.91-1.31 | 0.34 | 65.0 | 1.58 | 0.92-2.72 | 0.10 | 81.4 | 1.15 | 0.93-1.41 | 0.20 | 74.9 | 1.68 | 1.14-2.49 | 0.01 | 69.9 | ||||
| PB | 1 | 1.33 | 0.99-1.78 | 0.06 | NA | 1.24 | 0.85-1.80 | 0.26 | NA | 1.94 | 0.90-4.18 | 0.09 | NA | 1.33 | 0.93-1.89 | 0.12 | NA | 1.80 | 0.84-3.83 | 0.13 | NA | ||||
| Genotype method | |||||||||||||||||||||||||
| PCR-RFLP | 11 | 1.29 | 1.18-1.41 | <0.01 | 39.0 | 1.17 | 1.05-1.31 | <0.01 | 0 | 2.06 | 1.62-2.63 | <0.01 | 31.6 | 1.26 | 1.14-1.40 | <0.01 | 10.5 | 1.96 | 1.54-2.49 | <0.01 | 22.5 | ||||
| Others | 2 | 0.83 | 0.31-2.21- | 0.71 | 96.0 | 0.46 | 0.06-3.49 | 0.45 | 95.7 | 0.55 | 0.04-7.79 | 0.66 | 96.7 | 0.46 | 0.05-4.01 | 0.48 | 96.7 | 1.08 | 0.35-3.31 | 0.90 | 89.6 | ||||
| Adjusted | |||||||||||||||||||||||||
| Total | 12 | 1.32 | 1.18-1.79 | <0.01 | 45.6 | 1.20 | 1.08-1.34 | <0.01 | 0 | 1.58 | 0.93-2.70 | 0.09 | 82.0 | 1.12 | 0.73-1.70 | 0.61 | 87.0 | 1.94 | 1.26-3.00 | <0.01 | 16.6 | ||||
| Sensitive analysis# | 10 | 1.32 | 1.18-1.79 | <0.01 | 45.6 | 1.20 | 1.08-1.34 | <0.01 | 0 | 1.99 | 1.49-2.66 | <0.01 | 32.4 | 1.39 | 1.21-1.61 | <0.01 | 21.8 | 1.94 | 1.26-3.00 | <0.01 | 16.6 | ||||
| Location | |||||||||||||||||||||||||
| Digestive system | 5 | 1.41 | 1.27-1.55 | <0.01 | 0 | 1.30 | 1.12-1.51 | <0.01 | 0 | 2.42 | 1.76-3.33 | <0.01 | 0 | 1.44 | 1.16-1.79 | <0.01 | 14.0 | 2.45 | 1.44-4.15 | <0.01 | 0 | ||||
| Head and neck | 3 | 1.20 | 0.86-1.67 | 0.29 | 71.2 | 1.09 | 0.79-1.51 | 0.60 | 50.4 | 1.65 | 0.82-3.33 | 0.16 | 52.7 | 1.73 | 1.12-2.67 | 0.01 | NA | NA | NA | NA | NA | ||||
| Lung | 1 | NA | NA | NA | NA | NA | NA | NA | NA | 0.14 | 0.07-0.29 | <0.01 | NA | 0.15 | 0.07-0.32 | <0.01 | NA | NA | NA | NA | NA | ||||
| Cervical | 2 | 1.69 | 1.22-2.34 | <0.01 | NA | 1.20 | 0.96-1.51 | 0.12 | 0 | 2.19 | 0.69-6.96 | 0.18 | 72.3 | 1.32 | 0.92-1.88 | 0.13 | 55.6 | 1.22 | 0.57-2.60 | <0.01 | NA | ||||
| Breast | 1 | 0.94 | 0.65-1.35 | 0.74 | NA | 0.98 | 0.66-1.46 | 0.92 | NA | 0.78 | 0.28-2.19 | 0.64 | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||||
| Design | |||||||||||||||||||||||||
| HB | 11 | 1.32 | 1.16-1.50 | <0.01 | 51.6 | 1.18 | 1.05-1.31 | <0.01 | 0 | 1.52 | 0.86-2.69 | 0.15 | 83.3 | 1.01 | 0.62-1.65 | 0.97 | 88.9 | 1.85 | 0.85-4.01 | 0.12 | 57.7 | ||||
| PB | 1 | 1.35 | 1.02-1.79 | 0.04 | NA | 1.64 | 1.08-2.50 | 0.02 | NA | 12.56 | 1.05-6.25 | 0.04 | NA | 1.75 | 1.16-2.65 | <0.01 | NA | 2.08 | 0.87-4.96 | 0.10 | NA | ||||
| Genotype method | |||||||||||||||||||||||||
| PCR-RFLP | 10 | 1.31 | 1.14-1.50 | <0.01 | 49.3 | 1.19 | 1.06-1.33 | <0.01 | 3.7 | 2.00 | 1.55-2.59 | <0.01 | 39.1 | 1.39 | 1.21-1.61 | <0.01 | 21.8 | 1.94 | 1.26-3.00 | <0.01 | 16.6 | ||||
| Others | 2 | 1.42 | 1.21-1.66 | <0.01 | NA | 1.31 | 0.93-1.84 | 0.12 | NA | 0.52 | 0.04-6.70 | 0.62 | 96.6 | 0.15 | 0.07-0.32 | <0.01 | NA | NA | NA | NA | NA | ||||
* Numbers of comparisons
a Test for heterogeneity
# Sensitive analysis without the report of Hu et al.