| Representativeness of cases |
|
| Consecutive/randomly selected form case population with clearly defined sampling frame |
2 |
| Consecutive/randomly selected form case population without clearly defined sampling frame or with extensive |
1 |
| Not described |
0 |
| Source of controls |
|
| Population- or Healthy-based |
2 |
| Hospital-bases |
1 |
| Not described |
0 |
| Hardy-Weinberg equilibrium in controls |
|
| Hardy-Weinberg equilibrium |
2 |
| Hardy-Weinberg disequilibrium |
1 |
| Genotyping examination |
|
| Genotyping done under “blinded” condition |
1 |
| Unblinded done or not mentioned |
0 |
| Association assessment |
|
| Assess association between genotypes and cancer with appropriate statistics and adjustment for confounders |
2 |
| Assess association between genotypes and cancer with appropriate statistics and without adjustment for confounders |
1 |
| Inappropriate statistics used |
0 |
