Table 5. Diagnostic Efficacy of Different Criteria.
| Criteria | No | Sensitivity | Specificity | AUC (SE) | |
|---|---|---|---|---|---|
| 1. MRI | |||||
| Short Axis | >4mm | 2 | 0.78[0.69,0.86] | 0.89[0.85,0.92] | |
| >5mm | 2 | 0.58[0.43,0.72] | 0.72[0.69,0.75] | ||
| >6mm | 2 | 0.50[0.35,0.65] | 0.85[0.83,0.88] | ||
| >7mm | 2 | 0.46[0.31,0.61] | 0.91[0.89,0.93] | ||
| >8mm | 5 | 0.60[0.53,0.68] | 0.91[0.89,0.93] | 0.8071(0.0674) | |
| >9mm | 2 | 0.33[0.20,0.48] | 0.98[0.96,0.99] | ||
| >10mm | 18 | 0.47[0.42,0.51] | 0.86[0.84,0.87] | 0.7164(0.0566) | |
| >10mm and/or central necrosis | 1 | 0.45[0.23,0.68] | 0.91[0.85,0.95] | ||
| >12mm | 1 | 0.35[0.20,0.53] | 1.00[0.98.1.00] | ||
| >14mm | 1 | 0.24[0.12,0.41] | 1.00[0.98,1.00] | ||
| >16mm | 1 | 0.05[0.01,0.18] | 1.00[0.98,1.00] | ||
| Long Axis | >8mm | 2 | 0.82[0.72,0.89] | 0.47[0.44,0.50] | |
| >9mm | 1 | 0.93[0.82,0.99] | 0.66[0.58,0.74] | ||
| >10mm | 4 | 0.69[0.56,0.79] | 0.84[0.63,0.94] | 0.7832(0.0497) | |
| >10mm and central necrosis | 1 | 0.18[0.07,0.33] | 1.00[1.00,1.00] | ||
| >12mm | 3 | 0.52[0.39,0.64] | 0.87[0.85,0.90] | 0.8177(0.1129) | |
| >14mm | 3 | 0.45[0.32,0.57] | 0.91[0.89,0.93] | 0.8133(0.1636) | |
| >16mm | 2 | 0.20[0.10,0.34] | 0.96[0.94,0.98] | ||
| >18mm | 1 | 0.16[0.06,0.32] | 1.00[0.98,1.00] | ||
| >20mm | 1 | 0.14[0.05,0.29] | 1.00[0.98,1.00] | ||
| Ratio (short:long) | >0.5 | 1 | 0.83[0.52,0.98] | 0.45[0.40,0.50] | |
| >0.6 | 1 | 0.50[0.21,0.79] | 0.73[0.68,0.77] | ||
| >0.7 | 2 | 0.64[0.51,0.76] | 0.73[0.69,0.77] | ||
| >0.8 | 3 | 0.51[0.40-0.62] | 0.87[0.84,0.90] | 0.6772(0.0684) | |
| >0.9 | 1 | 0.08[0.00,0.38] | 0.96[0.94,0.98] | ||
| ≥1.3 | 1 | 0.47[0.23,0.72] | 0.86[0.75,0.94] | ||
| Miscellaneous | Extracapsular spread | 1 | 0.15[0.08,0.26] | 1.00[0.96,1.00] | |
| Lobulated | 2 | 0.57[0.34,0.78] | 0.83[0.79,0.86] | ||
| Spiculated | 2 | 0.20[0.04,0.48] | 0.99[0.97,0.99] | ||
| Indistinct | 1 | 0.00[0.00,0.26] | 0.98[0.96,0.99] | ||
| Necrosis | 1 | 0.21[0.12,0.33] | 0.94[0.87,0.98] | ||
| 4-point grading system | 2 | 0.38[0.25,0.53] | 0.93[0.87,0.97] | ||
| 2. DWI | |||||
| Short Axis | >10mm | 2 | 0.77[0.61,0.89] | 0.92[0.87,0.95] | |
| Mean ADC | <0.0005 | 1 | 0.25[0.05,0.57] | 0.93[0.90,0.95] | |
| <0.00055 | 1 | 0.25[0.05,0.57] | 0.85[0.81,0.88] | ||
| <0.0006 | 1 | 0.33[0.10,0.65] | 0.76[0.71,0.80] | ||
| <0.00065 | 1 | 0.33[0.10,0.65] | 0.74[0.69,0.78] | ||
| <0.0007 | 1 | 0.75[0.43,0.95] | 0.51[0.46,0.56] | ||
| <0.0008 | 1 | 0.92[0.62,1.00] | 0.27[0.23,0.32] | ||
| <0.0009 | 4 | 0.86[0.79,0.92] | 0.79[0.77,0.82] | 0.8606(0.1267) | |
| <0.00109 | 2 | 0.92[0.82,0.98] | 0.83[0.78,0.88] | ||
| <0.00115 | 3 | 0.79[0.71,0.86] | 0.82[0.76,0.87] | ||
| Mean eADC | >0.335 | 1 | 0.71[0.57,0.83] | 0.73[0.60,0.84] | |
| Minimum ADC | <0.000798 | 1 | 1.00[0.59,1.00] | 0.99[0.95,1.00] | |
| <0.000807 | 1 | 1.00[0.59,1.00] | 0.98[0.93,1.00] | ||
| <0.00086 | 2 | 0.89[0.82,0.94] | 0.74[0.70,0.77] | ||
| ≤0.634 | 1 | 0.93[0.82,0.99] | 0.91[0.85,0.95] | ||
| Max ADC | <0.00097 | 1 | 0.79[0.67,0.87] | 0.77[0.73,0.80] | |
| <0.00183 | 1 | 0.92[0.80,0.98] | 0.75[0.62,0.85] | ||
| Relative ADC | <0.00028 | 1 | 0.80[0.69,0.89] | 0.72[0.62,0.81] | |
| <0.00072 | 1 | 0.85[0.71,0.94] | 0.92[0.86,0.96] | ||
| 3. CT | |||||
| Short Axis | >8mm | 1 | 0.65[0.38,0.86] | 0.81[0.66,0.91] | |
| >10mm | 7 | 0.36[0.29,0.44] | 0.93[0.92,0.94] | 0.6120(0.0905) | |
| Long Axis | >9mm | 1 | 0.71[0.44,0.90] | 0.86[0.71,0.95] | |
| >10mm | 2 | 0.63[0.52,0.73] | 0.94[0.91,0.96] | ||
| >10mm and central necrosis | 1 | 0.27[0.12,0.48] | 1.00[1.00,1.00] | ||
| >14mm | 5 | 0.41[0.32,0.50] | 0.98[0.96,0.99] | 0.8331(0.0968) | |
| >20mm | 1 | 0.75[0.43,0.95] | 0.91[0.75,0.98] | ||
| Ratio (long:short) | ≥1.3 | 1 | 0.41[0.18,0.67] | 0.86[0.71,0.95] | |
| Miscellaneous | 4-point grading system | 1 | 0.31[0.11,0.59] | 0.99[0.93,1.00] | |
| 4. PET | |||||
| FDG uptake | Increased | 5 | 0.57[0.42,0.71] | 0.97[0.95,0.99] | 0.9370(0.1071) |
| close to primary tumor | 1 | 1.00[0.16,1.00] | 1.00[0.72,1.00] | ||
| Miscellaneous | 4-point grading system | 1 | 0.31[0.11,0.59] | 0.96[0.89,0.99] | |
| 5-point grading system | 1 | 0.60[0.15,0.95] | 0.99[0.92,1.00] | ||
| 5. PET-CT | |||||
| FDG uptake | Increased | 13 | 0.54[0.46,0.61] | 0.98[0.97,0.98] | 0.7498(0.1871) |
| SUV | >11.0 | 1 | 0.73[0.54,0.87] | 0.93[0.88,0.96] | |
| >2 and short >10mm | 1 | 0.91[0.71,0.99] | 0.95[0.88,0.99] | ||
| Max SUV | >3.0 | 1 | 0.71[0.29,0.96] | 0.95[0.82,0.99] | |
| >8.1 | 1 | 0.83[0.36,1.00] | 0.91[0.84,0.96] | ||
| >=2.5 and short axis>5mm | 1 | 0.69[0.39,0.91] | 0.97[0.91,0.99] | ||
| Miscellaneous | 5-point grading system | 2 | 0.79[0.67,0.88] | 0.92[0.87,0.96] | |