Table 2a. List of miRNAs with different roles in HCC.

miRNAs	Tumor associated	Role	Expression in tissue	Notes	Ref.
miR-18, p-miR-18, -224	HCC	Diagnostic	Higher expression levels of these miRNAs in HCC samples compared with normal tissue	-	[20, 21]
miR-199a,-199a*,-195, 200a, -125a	HCC	Diagnostic	Lower expression levels of these miRNAs in HCC samples compared with normal tissue	-	[20, 21]
miR- 92, -20, -18	HCC	Diagnostic	Expression levels were inversely related with HCC degree of differentiation		[20, 21]
miR-99a, -124, -139, -145 and -199b	HCC	Prognostic		Downregulation of these miRNAs was significantly associated with poor prognosis, shorter disease-free survival and features of metastatic tumors including venous invasion, microsatellite formation, absence of tumor encapsulation and reduced differentiation	[65]
miR-222, -135a, -155, -182, -10b, -17-5p,-221 and -21	HCC	Prognostic		Up-regulation of these miRNAs correlated with poor prognosis, such as increased risk of tumor recurrence and shorter overall survival	[65]
miR-122	HCC	Predictive of response to therapy	-	Restoration of miR-122 in HCC cells makes them sensitive to adriamycin and vincristine through down-regulation of Multidrug resistance (MDR)- related genes, the antiapoptotic gene Bcl-w and cyclin B1; it is also able to sensitize HCC cells to sorafenib	[76]
miR-122, -199a-3p	HCC	Predictive of response to therapy		These miRNAs affect sensitivity of HCC cells to doxorubicin	[76]
miR-21/anti-miR-21	HCC	Predictive of response to therapy		HCC cells transfected with pre–miR-21 were resistant to interferon-a (IFN-a)/5-FU, while cells expressing anti–miR-21 became sensitive to IFN-a/5- FU. Moreover, miR-21 expression in surgical HCC specimens was associated with the clinical response to the IFN-a/5-FU combination therapy and survival rate	[76]
miR-146a	HCC	Predictive of response to therapy		Induces resistance to interferon treatment through its ability to down-regulate SMAD4	[76]
miR-26	HCC	Predictive of response to therapy		Its low expression increases patients’ response to interferon therapy	[76]
miR-1274a	HCC	Predictive of response to therapy		Sorafenib was found to alter the expression of 14 miRNAs; among these miRNAs is miR-1274a, which is up-regulated by sorafenib resulting in repression of ADAM9, a protease involved in sorafenib targeted therapy	[76]