| miR-22, -125a, -127, -199a, -214, -376a, -424 |
CCA |
Diagnostic |
These miRNAs are down-regulated in intrahepatic cholangiocarcinoma (ICC) cells |
These miRNAs could be served as potential diagnostic biomarkers for ICC |
[194] |
| miR-21, -142-3p, -25, -15a, -193, -17-5p, -374, -106a, -224, -130b, -19a, -331, -324-5p, -20, 17-3p, -223, -15b, -103 |
CCA |
Diagnostic |
These miRNAs are up-regulated in ICC when compared with normal cholangiocytes |
- |
[195] |
| miR-98, -204, -338, -198, -302d, -328, -337, -302b, -184, -320, -371, -185, -222, -214, -373, -145, -200c, let-7a, let-7b, -197 |
CCA |
Diagnostic |
These miRNAs are down-regulated in ICC when compared with normal cholangiocytes |
- |
[195] |
| miR-21, -135b, -122, -27a, -29a, -429, -24, -203, -106b, -29b, -20a/-20b, -93, -30e, -30b, -151-3p, -10a, -181a, -96, -663b, -103, -221, -22, -107, -424, -340 |
CCA |
Diagnostic |
These miRNAs are up-regulated in CCA when compared with normal cholangiocytes |
- |
[196] |
| miR-451, -145, -99a, -125b, -630, let-7c, -144, -100, -127-3p, -139-5p, -337-3p, -1, -126, -376c, -517c+-519a, -520e |
CCA |
Diagnostic |
These miRNAs are down-regulated in CCA when compared with normal cholangiocytes |
|
[196] |
| miR-30c, -96, -30b, -100, -145, -125b, -127-3p |
CCA |
Diagnostic |
miR-30c, -96, -30b, are up-regulated in CCA compared with pancreatic adenocarcinoma (PC); miR-100, -145, -125b, -127-3p are down-regulated in CCA compared (PC) |
These specific miRNAs could be of aid in the differential diagnosis between these two neoplasms |
[196] |
| miR-192, -675-5p, -652-3p, -338-3p, -126, -21 |
CCA |
Prognostic |
|
Decreased OS has been significantly associated with up-regulation of these miRNAs |
[197–201] |
| miR-151-3p, -373 |
CCA |
Prognostic |
|
Decreased OS has been significantly associated with down-regulation of these miRNAs |
[197–201] |
| miR-192, -21,-214 |
CCA |
Prognostic |
|
Nodal metastases have been found more frequently in patients with up-regulation of these miRNAs |
[197, 200, 201] |
| Let-7g and miR-181b |
CCA |
Predictive of response to therapy |
|
These miRNAs can alter the response to 5-fluorouracil-based antimetabolite S-1 and miRNAs of the Let-7 family can induce radio-sensibility |
[219] |
| miR-21 and miR-200b |
CCA |
Predictive of response to therapy |
|
These miRNAs can increase chemo-resistance to gemcitabine by interacting PTEN and PTPN12 respectively in CCA cell lines |
[220] |
| miR-29b,-205, -221 |
CCA |
Predictive of response to therapy |
|
Downregulation of these miRNAs also present chemo-resistance to gemcitabine in CCA. Furthermore, PIK3R1 is identified as the common target of miR-29b and miR-221 |
[221] |
