Table 3. Univariate and multivariate analyses of the overall survival rate according to the clinicopathologic variables.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age | > 60 vs. ≤ 60 years | 1.281 | 0.741–2.212 | 0.375 | - | - | - |
| Gender | male vs. female | 1.553 | 0.798–3.024 | 0.195 | - | - | - |
| Tumor size | > 6 cm vs. ≤ 6 cm | 1.899 | 1.088–3.312 | 0.024* | 0.980 | 0.535–1.795 | 0.947 |
| Histology | undifferentiated vs. differentiated | 1.993 | 1.023–3.881 | 0.043* | 1.849 | 0.941–3.633 | 0.075 |
| Lauren classification | diffuse/mixed vs. intestinal | 1.541 | 0.862–2.754 | 0.145 | - | - | - |
| T stage | T3/4 vs. T1/2 | 4.356 | 1.351–14.042 | 0.014* | 1.479 | 0.402–5.441 | 0.556 |
| N stage | N2/3 vs. N0/1 | 3.883 | 2.022–7.458 | < 0.001* | 2.858 | 1.371–5.958 | 0.005* |
| LVI | present vs. absent | 2.374 | 1.218–4.628 | 0.011* | 1.197 | 0.590–2.432 | 0.618 |
| PNI | present vs. absent | 1.950 | 1.113–3.414 | 0.02* | 1.420 | 0.793–2.542 | 0.238 |
| IGFBP2 | high vs. low | 5.221 | 1.625–16.769 | 0.006* | 3.749 | 1.107–12.695 | 0.034* |
HR, hazard ratio; CI, confidential interval; LVI, lymphovascular invasion; PNI, perineural invasion.
*Significant at P < 0.05.