Table 4. Diagnostic performances of age, PLT, qAnti-HBc, APRI and Fib-4 in HBeAg (+) and HBeAg (−) patients.
| Group | Baseline value | AUROC | 95% CI | Cut-off | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
| HBeAg (+) | Age, years | 0.729 | 0.683–0.776 | 32.50 | 55.38% | 80.95% | 65.85% | 73.23% |
| PLT, 109/L | 0.703 | 0.654–0.752 | 176.50 | 60.51% | 74.49% | 61.14% | 73.99% | |
| qAnti-HBc, log10IU/mL | 0.734 | 0.689–0.778 | 4.58 | 63.08% | 74.83% | 62.44% | 75.34% | |
| APRI | 0.847 | 0.810–0.884 | 0.25 | 81.03% | 77.89% | 70.85% | 86.09% | |
| FIB-4 | 0.836 | 0.797–0.875 | 1.30 | 65.13% | 93.54% | 86.99% | 80.17% | |
| HBeAg (−) | PLT, 109/L | 0.761 | 0.678–0.843 | 162.5 | 65.96% | 82.93% | 89.86% | 51.52% |
| qAnti-HBc, log10IU/mL | 0.707 | 0.612–0.801 | 4.37 | 75.53% | 56.10% | 79.78% | 50.00% | |
| APRI | 0.824 | 0.750–0.899 | 0.43 | 64.89% | 87.80% | 92.42% | 52.17% | |
| FIB-4 | 0.821 | 0.742–0.900 | 1.33 | 76.60% | 82.93% | 91.14% | 60.71% |