Table 1. CLL patient characteristics.
| Patient Number | Sex | Rai | Binet | Surface CD38 Expression | ZAP-70 | Cytogenetics | IGHV Mutation Status | Treatment |
|---|---|---|---|---|---|---|---|---|
| USA Patients | ||||||||
| 1 | F | 0 | A | − | − | Normal | N/A | No |
| 2 | F | 2 | B | + | + | 17p- | N/A | No |
| 3 | F | 0 | A | − | − | 11q-, 13q- | N/A | No |
| 4 | F | 3 | C | + | + | +12 | Mutated | Yes |
| 5 | M | 0 | N/A | − | − | 13q- x2, partial deletion IgH | N/A | No |
| 6 | M | 0 | A | − | − | 13q- | Mutated | No |
| 7 | M | 1 | B | N/A | N/A | 13q- | N/A | No |
| 8 | F | 1 | B | − | − | 13q- x2 | Mutated | No |
| 9 | F | 1 | B | − | + | 13q- | N/A | No |
| Italy Patients | ||||||||
| 1 | F | 0 | A | − | − | 13q- | Mutated | No |
| 2 | M | 0 | A | − | + | 11q- | Unmutated | Yes |
| 3 | M | 0 | A | − | − | Normal | Mutated | No |
| 4 | F | 0 | A | − | + | Normal | Mutated | No |
| 5 | F | 0 | A | − | N/A | 13q- | Mutated | No |
| 6 | M | 0 | A | − | − | 13q- | Unmutated | No |
| 7 | M | 0 | A | − | − | 13q- | Mutated | No |
| 8 | F | 0 | A | − | + | 13q- | Mutated | Yes |
| 9 | F | 0 | A | − | − | 13q- | Mutated | No |
| 10 | F | 0 | A | − | N/A | N/A | Mutated | Yes |
| 11 | F | N/A | A | − | − | N/A | Mutated | Yes |
| 12 | M | N/A | A | − | − | Normal | Mutated | No |
| 13 | F | 0 | A | + | N/A | Normal | Unmutated | No |
| 14 | M | 0 | A | − | N/A | Normal | Unmutated | No |
| 15 | F | 0 | A | − | N/A | Normal | Unmutated | No |
| 16 | M | 0 | A | − | N/A | 13q- | N/A | No |
| 17 | M | 1 | A | + | N/A | N/A | N/A | No |
| 18 | F | 0 | A | + | N/A | Normal | Mutated | No |
| 19 | M | 0 | A | − | N/A | N/A | Unmutated | No |
| 20 | M | 0 | A | − | N/A | N/A | Mutated | No |
| 21 | M | N/A | B | N/A | + | 13q- | Unmutated | Yes |
| 22 | M | 2 | A | + | − | +12 | Unmutated | Yes |
| 23 | M | 1 | A | − | − | 13q- | Mutated | No |
| 24 | F | 0 | A | + | + | 17p- | Unmutated | Yes |
| 25 | M | 0 | A | + | − | 17p- | Unmutated | Yes |
| 26 | M | 0 | A | − | − | 17p- | Mutated | Yes |
| 27 | M | 0 | A | − | N/A | 13q- | Mutated | No |
| 28 | M | 1 | A | − | + | +12 | Mutated | No |
| 29 | F | 0 | A | − | N/A | 17p- | Unmutated | Yes |
| 30 | M | 0 | A | − | − | 13q- | Mutated | No |
| 31 | M | 1 | A | + | − | N/A | Unmutated | No |
| 32 | M | 0 | A | + | N/A | Normal | Unmutated | No |
| 33 | M | 0 | A | + | N/A | 11q- | Unmutated | Yes |
N/A: Not available; CD38 expression is defined + if > 20%; IGHV is considered mutated if homology to the genomic sequenced is < 98%; Intracellular ZAP-70 was measure by flow cytometry and consider + if > 30%.