Table 1. Methylation patterns of CpG sites on toll like receptors between Kawasaki disease patients and control subjects.

Target ID	Symbol	Fold-Change (KD1 vs. HC)	p-value (KD1 vs. HC)	Fold-Change (KD1 vs. FC)	p-value (KD1 vs. FC)	Fold-Change (KD2 vs. KD1)	p-value (KD2 vs. KD1)
cg02016764	TLR1	1.01476	0.368	1.05872	0.001*	1.01892	0.251
cg08757862		−1.01801	7.79E-06*	1.0037	0.312	1.00642	0.083
cg09316306		−1.05901	2.06E-09*	−1.01487	0.071	1.06207	5.26E-10*
cg22839308		−1.01643	6.46E-06*	−1.00921	0.007*	1.01972	1.73E-07*
cg02345613	TLR2	−1.00936	0.02*	−1.00508	0.197	−1.0018	0.646
cg03523945		−1.01976	4.84E-08*	−1.01223	0.000*	1.01281	0.000*
cg03610073		−1.0096	0.248	−1.00462	0.575	−1.02875	0.001*
cg06405222		−1.00235	0.397	1.00353	0.206	−1.01922	4.88E-09*
cg06618866		−1.0313	2.42E-06*	−1.02716	0.000*	1.00971	0.105
cg15852258		1.00144	0.571	1.00659	0.012*	1.0127	5.92E-06*
cg16547110		1.0028	0.259	1.00607	0.016*	−1.01118	3.00E-05*
cg17916835		−1.01637	0.007*	−1.00295	0.612	1.00299	0.608
cg19037167		−1.02192	2.37E-07*	−1.01582	0.000*	1.00948	0.013*
cg02821380	TLR3	−1.00465	0.913	1.00428	0.920	−1.03928	0.365
cg06498520		−1.0229	0.012*	−1.03399	0.000*	1.06263	4.44E-09*
cg12281049		−1.00299	0.256	−1.01884	0.000*	1.01653	4.83E-08*
cg23601030		1.00011	0.994	1.02091	0.151	−1.03026	0.04*
cg04061482	TLR4	1.00672	0.861	1.01445	0.707	−1.00803	0.834
cg05429895		−1.01334	1.57E-06*	−1.01838	0.000*	1.02266	1.35E-12*
cg13730105		−1.15383	5.19E-09*	−1.08378	0.000*	1.11546	2.31E-06*
cg00255925	TLR5	1.00094	0.774	1.01447	0.000*	−1.02364	1.63E-09*
cg01181681		1.05831	0.001*	1.03307	0.048*	−1.0815	9.88E-06*
cg03702975		1.0162	0.021*	−1.00727	0.290	−1.01852	0.009*
cg04219417		1.04379	0.002*	1.02063	0.131	−1.07478	1.36E-06*
cg05696109		−1.00085	0.742	−1.00095	0.703	1.01726	5.81E-09*
cg05858079		−1.01157	0.041*	−1.00032	0.954	−1.02197	0.000*
cg07015886		1.05173	0.001*	1.03711	0.012*	−1.09629	1.93E-08*
cg07538512		−1.00577	0.056	1.00421	0.159	1.01089	0.001*
cg07574686		−1.00294	0.515	−1.00419	0.355	−1.00194	0.667
cg09025215		1.04164	0.001*	1.02776	0.028*	−1.04867	0.000*
cg12275981		1.02507	0.001*	−1.00798	0.259	−1.01615	0.025*
cg12900151		−1.01145	0.608	−1.00222	0.920	−1.06584	0.006*
cg13557530		−1.00724	0.103	1.00232	0.598	−1.0567	4.69E-18*
cg14015211		−1.00305	0.238	1.00024	0.926	−1.02511	1.40E-13*
cg14228103		1.02911	0.512	1.02499	0.573	−1.08018	0.082
cg17599809		1.00068	0.568	1.00109	0.364	1.00403	0.001*
cg02221520	TLR6	−1.20594	7.72E-11*	−1.10954	0.000*	1.12684	4.16E-06*
cg04840108		−1.16201	1.24E-10*	−1.07016	0.001*	1.08012	0.000*
cg10182418		−1.02683	0.0004707*	−1.02678	0.000*	1.0643	4.70E-12*
cg14578677		−1.27206	3.13E-10*	−1.1577	0.000*	1.17843	2.84E-06*
cg14665413	TLR6	−1.19162	1.03E-10*	−1.10811	0.000*	1.13703	3.14E-07*
cg26681822		−1.03278	0.002*	1.01637	0.114	1.03694	0.001*
cg00321644	TLR7	−1.0028	0.592	1.01247	0.020*	−1.00222	0.67
cg06896988		−1.01684	0.135	−1.0093	0.404	1.0084	0.451
cg07210784		−1.00313	0.084	1.00278	0.123	−1.00056	0.751
cg13581155		1.01088	0.61	1.01588	0.458	−1.01742	0.416
cg24735671		−1.10476	2.04E-06*	−1.065	0.001*	1.0535	0.008*
cg00741717	TLR8	−1.03908	0.001*	−1.01974	0.090	−1.00236	0.836
cg07759587		−1.18112	1.26E-06*	−1.1118	0.001*	1.09883	0.003*
cg13153942		−1.04969	0.001*	−1.00852	0.540	−1.11606	8.14E-11*
cg01395047	TLR9	1.01946	0.002*	−1.00006	0.991	−1.01477	0.015*
cg01564045		−1.01836	0.094	−1.0039	0.717	−1.01216	0.263
cg04206665		−1.00824	0.031*	−1.00954	0.013*	1.002	0.592
cg05778154		−1.00788	0.02*	1.0002	0.951	−1.0244	8.99E-10*
cg06844837		−1.00343	0.361	1.00104	0.780	−1.01657	4.51E-05*
cg14528193		−1.00564	0.078	1.0032	0.314	−1.03085	1.46E-13*
cg16302310		−1.01916	0.002*	−1.02452	0.000*	−1.00813	0.173
cg21578541		−1.05103	8.00E-07*	−1.04956	0.000*	1.04769	2.94E-06*
cg22484793		1.01453	0.057	1.01557	0.042*	−1.03657	1.10E-05*
cg06935464	TLR10	−1.00773	0.058	−1.0043	0.285	1.02615	2.31E-08*
cg17671577		−1.00355	0.204	1.00433	0.123	−1.01443	2.88E-06*
cg19398783		−1.00751	0.002*	−1.0088	0.000*	1.01243	1.51E-06*
cg22128849		−1.00075	0.665	−1.00028	0.873	−1.00119	0.494
cg23855121		−1.03164	1.37E-06*	−1.02804	0.000*	−1.00137	0.813

KD1: Kawasaki disease prior to IVIG treatment; KD1: Kawasaki disease after IVIG treatment > 3 weeks; FC: febrile control; HC: healthy control.