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Our findings demonstrate that DP2 induces TLR2/4-ERK1/2 signal cascade that upregulates uPAR/uPA expression and secretion, contributing to enhancement of uPAR/integrin αV interaction, triggering the downstream FAK/Src, PI3K/AKT, and MAPK activation, increasing Rho A and MMP-2 expression, and consequently promoting cell migratory and invasive ability of NSCLC cell A549.
