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. 2017 Jan 5;8(7):11356–11371. doi: 10.18632/oncotarget.14529

Figure 3. MiR-410 promoted metastasis and drug resistance of NSCLC.

Figure 3

(A) and (B) In vitro Transwell assays of miR-410 overexpression or knock-down stable cells derived from A549 A. and H1299 B. cells. Mic and Mic-NC, miR-410 overexpression stable cells and its matched NC control stable cells; Inh and Inh-NC, miR-410 knock-down stable cells and its matched NC control stable cells. (C) and (D) In vitro Millicells assays of miR-410 overexpression or knock-down stable cells derived from A549 C. and H1299 D. cells. Mic and Mic-NC, miR-410 overexpression stable cells and its matched NC control stable cells; Inh and Inh-NC, miR-410 knock-down stable cells and its matched NC control stable cells. (E, F) and (G) Images of metastatic nodules in the lungs of mice (E) relative lung metastatic rate of each treatment group (F) and images of H&E staining with lung tissues of nude mice (G). Mic and Mic-NC, mice treated with miR-410 overexpression stable cells and its matched NC control stable cells; Inh and Inh-NC, mice treated with miR-410 knock-down stable cells and its matched NC control stable cells. (H) and (I) Cells vital rates of miR-410 overexpression or knock-down stable cells derived from A549 H. and H1299 I. cells were resistant to Cisplatin. IC50 was half maximal inhibitory concentration calculated by SPSS software. Mic and Mic-NC, miR-410 overexpression stable cells and its matched NC control stable cells ; Inh and Inh-NC, miR-410 knock-down stable cells and its matched NC control stable cells. *P < 0.05; **P < 0.01; ***P < 0.001. *compared with the relative NC control.