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. 2016 Dec 20;8(7):11489–11506. doi: 10.18632/oncotarget.14039

Figure 7. CHRDL2 blocks the BMP2 and attenuates the effect of promoting proliferation and inhibiting apoptosis induced by BMP2 in HCT116 cells.

Figure 7

A. Cell-cycle analysis by flow cytometry in HCT116 cells treated with 100 ng/ml BMP2 or 100 ng/ml CHRDL2. The histograms show the ratio of different cell phase populations (G0/G1, S and G2/M cells) in treated HCT116 cells. B. Apoptosis analysis by flow cytometry in HCT116 cells treated with 100 ng/ml BMP2 or 100 ng/ml CHRDL2. The histograms show the apoptosis rate in treated HCT116 cells. C. Western blot analysis was used to measure the P21, Cyclin D1, Cleaved caspase 9 and Cleaved caspase 3 in the lysis of HCT116 cells treated with 100 ng/ml BMP2 or 100 ng/ml CHRDL2.