Table 2. Univariate and multivariate analysis of overall survival in CRC patients.
| Variables | No. of cases. | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| HR ratio | 95%CI | P-value | HR ratio | 95%CI | P-value | ||
| Age(years) | 1.004 | 0.985-1.204 | 0.664 | ||||
| <60 | 76 | ||||||
| ≥60 | 49 | ||||||
| Gender | 1.007 | 0.625-1.853 | 0.79 | ||||
| Female | 59 | ||||||
| Male | 66 | ||||||
| Tumor diameter(cm) | 2.157 | 1.252-3.715 | 0.006** | 2.158 | 1.245-3.741 | 0.006** | |
| ≤5 | 71 | ||||||
| >5 | 54 | ||||||
| Tumor location | 0.664 | 0.377-1.169 | 0.156 | ||||
| Colon | 69 | ||||||
| Rectum | 56 | ||||||
| Depth of infiltration | 1.185 | 0.815-1.723 | 0.373 | ||||
| Submucosa, musculeris propria | 28 | ||||||
| Subserosa | 66 | ||||||
| To the surrounding tissue | 31 | ||||||
| Histologic type | 1.518 | 1.053-2.189 | 0.025* | 1.696 | 1.147-2.506 | 0.009** | |
| Well differentiated | 56 | ||||||
| Morderately differentiated | 49 | ||||||
| Poorly differentiated | 20 | ||||||
| TNM staging | 2.234 | 1.297-3.848 | 0.004** | 2.489 | 1.481-4.399 | 0.002** | |
| I/II | 81 | ||||||
| III/IV | 44 | ||||||
| Lymph node metastasis | 1.609 | 0.973-2.659 | 0.064 | ||||
| NO | 85 | ||||||
| YES | 40 | ||||||
| CHRDL2 expression | 2.231 | 1.275-3.905 | 0.005** | 2.139 | 1.207-3.791 | 0.009** | |
| Low | 63 | ||||||
| High | 62 | ||||||
NOTE: p values were derived by using Cox proportional hazards regression model. (* p< 0.05. ** p< 0.01).