Table 3. Univariate and multivariate survival analysis of disease-free survival in CRC patients.

Variables	No. of cases.	Univariate analysis			Multivariate analysis
		HR ratio	95%CI	P-value	HR ratio	95%CI	P-value
Age(years)		1.009	0.991-1.027	0.349
<60	76
≥60	49
Gender		0.911	0.554-1.498	0.713
Female	59
Male	66
Tumor diameter(cm)		0.566	0.3629-0.8826	0.012*	1.719	1.049-2.816	0.019*
≤5	71
>5	54
Tumor location		0.996	0.609-1.628	0.987
Colon	69
Rectum	56
Depth of infiltration		1.055	0.749-1.485	0.761
Submucosa, musculeris propria	28
Subserosa	66
To the surrounding tissue	31
Histologic type		1.61	1.155-2.245	0.005**	1.615	1.138-2.293	0.007**
Well differentiated	56
Morderately differentiated	49
Poorly differentiated	20
TNM staging		1.716	1.055-2.791	0.029*	1.849	1.119-3.057	0.007**
I/II	81
III/IV	44
Lymph node metastasis		1.811	1.099-2.983	0.02*
NO	85
YES	40
CHRDL2 expression		1.956	1.188-3.221	0.008**	1.956	1.188-3.221	0.008*
Low	63
High	62

NOTE: p values were derived by using Cox proportional hazards regression model. (* p< 0.05. ** p< 0.01).