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. 2016 Dec 24;8(7):11555–11565. doi: 10.18632/oncotarget.14135

Figure 2. Dexamethasone/hydrocortisone induces KLF5 expression in breast cancer cells.

Figure 2

A-C. KLF5 protein expression is induced by Dex in a time- and dose-dependent manner. HCC1937 (A), HCC1806 (B) or MCF10A (C) cells were treated with 1 μM Dex for the indicated time or for 4 h at the indicated concentrations. D. KLF5 protein expression is induced by Hydro in a time- and dose-dependent manner. MCF10A cells were treated with 1 μM Hydro for the indicated times or for 4 hours at the indicated concentrations. E. KLF5 expression is regulated by hydrocortisone in MCF10A cells. Removal of Hydro from the MCF10A culture medium down-regulates the KLF5 expression (upper panel), and adding back Hydro restored KLF5 expression (lower panel).