Table 2. Genetic variants of EGLN1/PHD2 gene and the risk of lung cancer.
| Patients | Controls | OR* | 95%CI | p-Value | OR** | 95%CI | p-Value | OR*** | 95%CI | p-Value | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| D4E | |||||||||||
| Wildtype | 174 | 192 | 1.00 | 0.0012 | 1.00 | 0.0109 | 0.0094 | ||||
| Heterozygous | 35 | 20 | 2.12 | (1.16-3.88) | 2.06 | (1.13-3.7) | 1.91 | (1.06-3.5) | |||
| Homozygous | 5 | 1 | 8.35 | (0.82-84.98) | 6.74 | (0.76-60) | 4.97 | (0.6-43.5) | |||
| Hetero/Homo | 40 | 21 | 2.35 | (1.31-4.22) | 2.26 | (1.27-4.0) | 2.06 | (1.16-3.6) | |||
| C127S | |||||||||||
| Wildtype | 74 | 101 | 1.00 | 0.0002 | 1.00 | 0.0018 | |||||
| Heterozygous | 102 | 94 | 1.60 | (1.05-2.42) | 1.52 | (1.00-2.3) | 1.43 | (0.94-2.2) | 0.0022 | ||
| Homozygous | 38 | 18 | 3.03 | (1.59-5.78) | 3.09 | (1.62-5.9) | 2.75 | (1.44-5.2) | |||
| Hetero/homo | 140 | 112 | 1.83 | (1.24-2.72) | 1.76 | (1.19-2.6) | 1.64 | (1.1-2.43) | |||
*
adjusting for ethnicity (Tibetan/non-Tibetan)
**
adjusting for religion (Hindu/not Hindu)
***
adjusting for rs142764723 and rs117813469