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. 2017 Jan 2;8(7):11937–11949. doi: 10.18632/oncotarget.14442

Figure 1. Combination treatment of BEZ235 and TSA leads to synergistic cytotoxic effect on breast cancer cells.

Figure 1

A. Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. B. BEZ235 and TSA showed synergistically killing effect on MCF-7, T47D and MDA-MB-231 cells. C. BEZ235 and TSA synergistically inhibited the colony formation of MCF-7, T47D and MDA-MB-231 cells by the plate colony forming assay. Fewer colonies were formed in the group treated with both BEZ235 and TSA compared with the control group and groups treated with either BEZ235 or TSA alone.