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. 2017 Jan 2;8(7):11937–11949. doi: 10.18632/oncotarget.14442

Figure 5. Co-treatment with BEZ235 and TSA enhanced autophagy in breast cancer cells.

Figure 5

A. MCF-7, T47D and MDA-MB-231 cells were treated with the indicated concentration of BEZ235 and/or TSA for 48 h. Then, the total cell lysates were prepared and western blot analyses were performed for autophy related protein (Beclin-1, LC3B). B. LC3B expression in breast cancer cells were visualized by immunoreflurensence. The combination group show greater punctuate pattern of LC3B staining, typical of autophagy compared with single drug group. C. 3-MA reduced the autophagy induced by co-treatment with BEZ235 and TSA, while enhanced the apoptosis in breast cancer cells.