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. 2017 Jan 2;8(7):11977–11989. doi: 10.18632/oncotarget.14450

Figure 3. LOXL4 knockdown increased primary tumor growth and lung metastasis of MDA-MB-231 breast cancer cells.

Figure 3

A. Changes in tumor volume after injection of MDA-MB-231 cells transduced with control or shLOXL4. B. Representative bioluminescence images of the tumors obtained with the IVIS system on day 41 after cancer cell injection. C. Total flux values (p/s/cm2/sr) measured in bioluminescence images (day 41) of the primary tumors. Control and shLOXL4, n = 4 and 5, respectively. D. Images of the final lung gross appearance and doxycycline-induced RFP in primary tumors. E. Representative bioluminescence images of tumor burdens in lungs obtained on day 56 after tail vein injections of cancer cells. n = 5. F. Total flux (p/s/cm2/sr) measured in bioluminescence images of the metastatic lung burden (day 56). G. Images of the final lung gross appearance, doxycycline-induced RFP in lung metastatic nodules, and H&E staining. Scale bar: 1 cm.