Table 3. Associations of age, BMI, WHR and PA with cognitive scores at 18-month follow-up interview (n=1286).
| Immediate memory score | Delayed memory score | Verbal fluency score | Attention score | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Absolute value | Relative value | Absolute value | Relative value | Absolute value | Relative value | Absolute value | Relative value | |||||||||||||
| Mean (SE) | P1 | Diff (SE) | P2 | P3 | Mean (SE) | P1 | Diff (SE) | P2 | P3 | Mean (SE) | P1 | Diff (SE) | P2 | P3 | Mean (SE) | P1 | Diff (SE) | P2 | P3 | |
| Age at 18-month follow-up interview (years)a | 0.002 | 0.003 | <0.001 | <0.001 | ||||||||||||||||
| <50 | 9.9 (0.3) | −1.0 (0.4) | 0.02 | 0.0498 | 9.1 (0.3) | −0.9 (0.4) | 0.03 | 0.08 | 42.1 (0.5) | −0.9 (0.7) | 0.24 | 0.71 | 80.6 (1.1) | −1.3 (1.6) | 0.42 | 1.00 | ||||
| 50-59 | 10.8 (0.2) | Reference | 10.0 (0.2) | Reference | 43.0 (0.4) | Reference | 81.9 (0.9) | Reference | ||||||||||||
| ≥60 | 9.7 (0.3) | −1.2 (0.4) | 0.001 | 0.004 | 8.9 (0.3) | −1.1 (0.4) | 0.002 | 0.006 | 40.2 (0.5) | −2.8 (0.7) | <0.001 | <0.001 | 65.5 (1.1) | −16.3 (1.4) | <0.001 | <0.001 | ||||
| BMI (kg/m2)b | 0.08 | 0.04 | 0.23 | <0.001 | ||||||||||||||||
| Underweight (<18.5) | 10.2 (1.1) | −0.3 (1.1) | 0.78 | 1.00 | 10.1 (1.0) | 0.3 (1.1) | 0.74 | 1.00 | 40.9 (1.9) | −1.5 (1.9) | 0.45 | 1.00 | 80.8 (4.0) | 1.9 (4.1) | 0.64 | 1.00 | ||||
| Normal (18.5-23.9) | 10.5 (0.2) | Reference | 9.8 (0.2) | Reference | 42.4 (0.4) | Reference | 78.9 (0.8) | Reference | ||||||||||||
| Overweight (24.0-27.9) | 10.1 (0.2) | −0.4 (0.3) | 0.17 | 0.99 | 9.2 (0.2) | −0.5 (0.3) | 0.07 | 0.42 | 41.8 (0.4) | −0.6 (0.5) | 0.30 | 1.00 | 76.3 (0.9) | −2.6 (1.2) | 0.03 | 0.15 | ||||
| Obese (≥28.0) | 9.4 (0.4) | −1.1 (0.4) | 0.01 | 0.07 | 8.6 (0.4) | −1.1 (0.4) | 0.010 | 0.06 | 40.9 (0.7) | −1.5 (0.8) | 0.05 | 0.32 | 71.8 (1.5) | −7.1 (1.7) | <0.001 | <0.001 | ||||
| WHRb | 0.002 | 0.002 | 0.55 | 0.003 | ||||||||||||||||
| Normal (<0.80) | 10.7 (0.3) | Reference | 9.9 (0.3) | Reference | 41.5 (0.5) | Reference | 78.9 (1.1) | Reference | ||||||||||||
| 0.80-0.84 | 10.6 (0.2) | −0.04 (0.4) | 0.92 | 1.00 | 9.8 (0.2) | −0.1 (0.4) | 0.85 | 1.00 | 42.3 (0.4) | 0.7 (0.7) | 0.27 | 0.81 | 78.7 (0.9) | −0.2 (1.4) | 0.89 | 1.00 | ||||
| Abdominally obese (≥0.85) | 9.6 (0.2) | −1.0 (0.4) | 0.004 | 0.01 | 8.9 (0.2) | −1.0 (0.4) | 0.004 | 0.01 | 42.0 (0.4) | 0.4 (0.7) | 0.51 | 1.00 | 75.0 (0.8) | −3.8 (1.4) | 0.006 | 0.02 | ||||
| PA (METs-hours/week)b | 0.74 | 0.41 | 0.09 | 0.16 | ||||||||||||||||
| Light-intensity (<8.3) | 10.1 (0.2) | −0.3 (0.4) | 0.44 | 1.00 | 9.3 (0.2) | −0.5 (0.4) | 0.18 | 0.55 | 41.5 (0.4) | −0.5 (0.6) | 0.47 | 1.00 | 76.3 (0.8) | −2.6 (1.4) | 0.06 | 0.17 | ||||
| Moderate-intensity (8.3-16.5) | 10.4 (0.3) | Reference | 9.7 (0.3) | Reference | 41.9 (0.5) | Reference | 78.9 (1.1) | Reference | ||||||||||||
| Vigorous-intensity (≥16.6) | 10.2 (0.2) | −0.2 (0.4) | 0.56 | 1.00 | 9.4 (0.2) | −0.3 (0.4) | 0.37 | 1.00 | 42.7 (0.4) | 0.8 (0.7) | 0.24 | 0.73 | 76.8 (0.9) | −2.1 (1.4) | 0.15 | 0.46 | ||||
aAdjusted for educational attainment, income, menopausal status at 18-month follow-up interview, depression score, stage of cancer, breast cancer recurrence or diagnosis of other malignancies before 18-month follow-up interview, cancer treatments (including surgery, radiotherapy, chemotherapy and tamoxifen use), and time since the cessation of cancer therapy at 18-month follow-up interview.
bAddtionally adjusted for age at 18-month follow-up interview
1P-value for the overall model significance
2P-value for the difference in mean cognitive scores at 18-month follow-up interview between this group and the reference group
3P-value for the difference in mean cognitive scores at 18-month follow-up interview between this group and the reference group after correcting for multiple comparisons using Bonferroni correction
Abbreviations: Mean, mean cognitive score at 18-month follow-up interview for patients in different groups of age, BMI, WHR and PA intensity; SE, standard error; Diff, difference in mean cognitive scores at 18-month follow-up interview between this group and the reference group