Table 2. Main molecular alterations of all preneoplastic colorectal lesions.

	Preneoplastic lesions	APC	KRAS	BRAF	CIMP	Microsatellite	CIN	MGMT
Serrated adenomas	MVHPs			Mutated	High	Stable
	GCHPs		Mutated		Low	Stable
	MPHPs				High
	SD-TSAs			Mutated	High	Stable
	CD-TSAs		Mutated		Low	Stable		Hypermethylated
	SSAs/Ps			Mutated	High	Instable
	CD-SSAs/Ps			Mutated	High	Instable
Conventional adenomas	TAs	Mutated	Mutated		Low	Stable	+
	TVAs	Mutated	Mutated		Low	Stable	+	Hypermethylated
	VAs	Mutated	Mutated		Low	Stable	+