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. 2016 Dec 2;8(7):12417–12432. doi: 10.18632/oncotarget.13778

Figure 1. The Myc interaction with the cell cycle machinery.

Figure 1

this figure is a simplified depiction of the role Myc oncoprotein in regulation of the cell cycle machinery. The normal cell replication processes are represented i.e., G1 first growth period to S DNA replication phase, G2 second growth period, and M, which is the mitosis period. Cyclin D2-CDK4 and CDK2 inactivate retinoblastoma protein (Rb) through phosphorylation. The latter event allows for cell cycle progression from G1 to S phase. Max/Myc complex targets cyclinD2-CDK4 complex formation ultimately stimulating cell cycle progression. Also cycle dependent kinase 2 (CDK2) complex activation is depicted through the abrogation of inhibitory action of Cki27 by active Max/Myc complex. When active CDK2 complex promotes initiation of S phase.