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. 2016 Dec 22;8(7):12451–12471. doi: 10.18632/oncotarget.14104

Figure 1. Gene and protein structure of PTOV1.

Figure 1

A. The gene includes 12 coding exons and two untranslated regions (UTR). In the putative promoter region, the localization of regulatory sites for ARE (Androgen Responsive Element), SP1 (Specificity protein 1), and AP2 (Activator protein 2) are shown (not in scale). B. Protein organization showing the A and B domains, the Nuclear Localization Sequences (NLS1 and NLS2) and the extended AT-hook (eAT-hook) motif (not in scale). The three-dimensional structure of the A and B domains based on the Swiss Model, is shown in color [13].