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. 2016 Dec 15;8(7):12472–12483. doi: 10.18632/oncotarget.13957

Table 1. selected EMT-related lncRNAs showing diverse mechanisms of action.

LncRNA Mechanisms of action References
MALAT-1 Interacts with suz12 resulting in suppression of E-cadherin and activation of N-cadherin and fibronectin. Affected by tumor micro-environment. Ji et al. [75]
Fan et al. [76]
Kan et al. [80]
HOTAIR Reprograms chromatin state. Qiu et al. [82]
Wu et al. [83]
Kim et al. [84]
BANCR Histone de-acetylation suppresses BANCR to promote EMT. Guo et al. [96]
Sun et al. [97]
H19 Chromatin modifier. Matouk et al. [85]
Linc00617 Stimulates EMT via activating the transcription of Sox2. Li et al. [86]
LncRNA-HIT Promotes TGF-β-induced EMT via downregulating the levels of E-cadherin. Richards et al. [98]
AOC4P Inhibits EMT via binding to vimentin and promoting its degradation. Wang et al. [87]
HULC Affected by tumor micro-environment. Matouk et al. [89]
LncTCF7 Affected by tumor micro-environment. Hamada et al. [63]
ZEB1-AS1 Upstream antisense RNA enhances ZEB1 expression. Li et al. [90]
Zeb2NAT Prevents splicing of the Zeb2 5’-UTR, increases Zeb2 and downregulates E-cadherin. Zhuang et al. [91]
91H H19 antisense. Associated with H19 ICR methylation. Deng et al. [92]
Gao et al. [93]

Abbreviations: AOC4P, amine oxidase, copper containing 4, pseudogene; BANCR, BRAF-activated non-protein coding RNA; EMT, epithelial-mesenchymal transition; HOTAIR, HOX transcript antisense RNA; HULC, highly up-regulated in liver cancer; lncRNA, long noncoding RNA; MALAT-1, metastasis-associated lung adenocarcinoma transcript 1; Sox2, SRY (sex determining region Y)-box 2; TGF-β, transforming growth factor beta; ZEB1/2, zinc-finger E-box-binding homeobox 1/2.