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. 2016 Nov 24;8(7):12517–12532. doi: 10.18632/oncotarget.13573

Table 3. LncRNAs participate in metastasis/invasion-promoting programs of CRC.

LncRNA In colorectal cancer, its expressions is: Functions Reference
CCAT1 Upregulated Promotes cell migration and invasion. [6]
BANCR Upregulated Induces EMT program through an MEK/extracellular signal-regulated kinase-dependent mechanism. [33]
LncRNA H19 Upregulated Promotes EMT in CRC. [34]
HOTAIR Upregulated Promotes migration and invasion, decreases expression of E-cadherin, increases expression of vimentin and MMP9 and associates with poorer prognosis. [36]
TUG1 Upregulated Increases the invasive and metastatic ability of CRC cells through activating EMT process [38]
FEZF1-AS1 Upregulated Promotes migration. [39]
CASC11 Upregulated Promotes CRC cell metastasis, dependent on activation of WNT/β-catenin signaling. [40]
91H Upregulated Promotes proliferation, migration, and invasiveness of CRC cells. [41]
LncRNA-CTD903 Downregulated Suppresses invasion and migration through repressing Wnt/β-catenin signaling. [42]
LncRNA TINCR Downregulated Suppresses CRC proliferation and metastasis by accelerating the cleavage of EpCAM and releasing EpICD via activating WNT/β- catenin pathway. [43]
ncRAN Downregulated Inhibits migration and invasion of CRC cells. [44]
ANRIL Upregulated Promotes cell invasion and migration. [61]