Table 4.
Proteins associated with siderophore biosynthesis and transporter activity with increased abundance in A. fumigatus ΔmirC mycelia grown for 72 h in iron-replete MM compared to A. fumigatus WT (See also Tables S3, S6, S7, S10 and S11).
| Protein description | Log2 (Fold Increase) | p-value | Peptides | Sequence coverage [%] | Protein IDs |
|---|---|---|---|---|---|
| Putative long-chain-fatty-acid-CoA ligase. SidI. | Unique | N/A | 38 | 75.8 | AFUA_1G17190 |
| Putative siderophore biosynthesis lipase/esterase. EstB. | Unique | N/A | 9 | 58.9 | AFUA_3G03660 |
| L-ornithine N5-oxygenase, first committed step in siderophore biosynthesis. SidA. | 6.42 | 2.55E-04 | 48 | 83.2 | AFUA_2G07680 |
| Putative siderophore iron transporter;SrbA-regulated during hypoxia. MirB. | 3.48 | 8.17E-03 | 9 | 26.1 | AFUA_3G03640 |
| Putative siderophore transporter;expression upregulated under low iron conditions. MirD. | 2.35 | 1.71E-03 | 7 | 13.2 | AFUA_3G03440 |
| Hydroxyornithine transacylase;involved in extracellular siderophore biosynthesis;essential for triacetylfusarinine C biosynthesis. SidF. | 2.01 | 1.76E-04 | 38 | 90 | AFUA_3G03400 |
| Putative siderophore transporter;SrbA-regulated during hypoxia. Sit1. | 1.73 | 4.72E-02 | 5 | 11.4 | AFUA_7G06060 |
| Putative siderophore biosynthesis lipase/esterase. SidJ. | 1.15 | 4.65E-03 | 15 | 66.7 | AFUA_3G03390 |