Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 17;8:398. doi: 10.3389/fmicb.2017.00398

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Ansell, Baker, Emery, McConville, Svärd, Gasser and Jex.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

A putative metronidazole efflux system in 106-r. V-type ATPases are inserted into vesicular membranes and transported via microtubules and dynein/kinesin motors to the plasma membrane. These pumps use ATP to transport protons out of the cytosol against the diffusion gradient. An up-regulated sodium/proton antiporter exchanges in-flowing protons for sodium, increasing the extracellular sodium concentration. The MATE transporter is proposed to expel metronidazole as sodium flows back into the cell. Up-regulated genes (prefix GL50803 abbreviated to GL) are displayed next to proteins.