Table 1.
States and parameters of IgG metabolism model.
| Name | Units | Physiological interpretation |
|---|---|---|
| x1 | µmol | Quantity of IgG in the central (plasma) compartment |
| x2 | µmol | Quantity of IgG in the peripheral (tissue) compartment |
| k21 | day−1 | Rate constant of flow of IgG from plasma to peripheral compartment |
| k31 | day−1 | Rate constant of flow of IgG from plasma into endosomes by pinocytosis |
| k12 | day−1 | Rate constant of flow of IgG from peripheral compartment to plasma |
| Vmax | µmol day−1 | Maximum absolute recycling rate |
| KM | µmol | Michaelis constant; the quantity of IgG in plasma at which the absolute recycling rate is half Vmax |