Table 1.
Characteristics of children with dilated cardiomyopathy and 6 min walk test result
| n = 49 | Time since diagnosis <1 year n = 14 | Time since diagnosis >1 year n = 35 | |
|---|---|---|---|
| Gender, male, n (%) | 26 (53) | 5 (36) | 21 (60) |
| Age, years | 11.9 (7.4–15.1) | 12.1 (8.6–16.0) | 11.8 (8.3–14.1) |
| Time since DCM diagnosis, years | 3.6 (0.6–7.4) | 0.1 (0.1–0.5) | 6.2 (3.1–9.2) |
| Cause of DCM, n (%) | |||
| Idiopathic | 24 (49) | 6 (43) | 18 (51) |
| Myocarditis | 7 (14) | 0 (0) | 7 (20) |
| Other | 18 (37) | 8 (57) | 10 (29) |
| Medication used, n (%) | |||
| Beta-blocker | 38 (78) | 9 (64) | 29 (91) |
| ACE-inhibitor | 46 (94) | 14 (100) | 32 (91) |
| Spironolactone | 27 (55) | 8 (57) | 19 (54) |
| Loop diuretics | 25 (51) | 8 (57) | 17 (49) |
| Digoxin | 8 (16) | 1 (7) | 7 (20) |
| NT-proBNP (pmol/L) | 221 (51–555) | 451 (248–735) | 102 (32–472) |
| LVEDD z-score | 5.0 ± 3.2 | 4.7 ± 2.1 | 5.2 ± 3.5 |
| Fractional shortening, % | 18 ± 6 | 15 ± 7 | 19 ± 6 |
| LV ejection fraction, % | 33 ± 12 | 25 ± 11 | 36 ± 12 |
| Endpoint, n (%) | 10 (20) | ||
| Death | 0 | ||
| Heart transplantation | 10 (100) | 3 | 7 |
| Follow-up since 6MWT, months | 33 (14–50) | 24 (12–31) | 45 (14–53) |
| 6MWD, m | 448 ± 144 | 401 ± 88 | 466 ± 88 |
| 6MWD%, % | 70 ± 21 | 62 ± 15 | 73 ± 22 |
Continuous variables are represented as mean ± SD if normally distributed and as median (IQR) if non-normally distributed
Cause of DCM—“Other” includes Anthracycline cardiomyopathy (5), familial (5); non-compaction cardiomyopathy (3), ischemia (2), arrhythmia (2)
6MWD indicates 6 min walk distance, 6MWD% 6 min walk distance as % of predicted, ACE angiotensin converting enzyme, DCM dilated cardiomyopathy, LVEDD left ventricular end-diastolic dimension