Table 2.

Univariate analysis for the LTA and development of complicated disease behaviour and hospitalizations

	Complicated disease behaviour			Hospitalization
	HR	95% CI	p value	HR	95% CI	p value
LTA	2.45	1.6–3.8	<0.0001	1.6	1.1–2.1	0.007
Age at diagnosis			0.92
A1				Ref
A2				0.55	0.34–0.89	0.015
A3				0.57	0.34–0.95	0.030
BMI			0.95
<18				Ref
18–26				0.67	0.42–1.1	0.102
>26				0.47	0.26–0.86	0.014
Location						0.43
Colonic	Ref
Ileal only	1.9	1.005–3.7	0.048
Ileocolonic	1.7	0.91–3.2	0.096
Upper GI	5.1	1.2–5.1	0.031
Behavior			0.19
B1				Ref
B2				1.6	1.2–2.4	0.006
B3				1.7	0.97–2.9	0.07
Perianal disease			0.39			0.9
Smoking			0.53			0.9
CRP at diagnosis	1.003	1.001–1.006	0.010			0.238
Sex			0.71	1.3	0.9–1.8	0.095

A1 = age at diagnosis <17 years; A2 = age at diagnosis between 17 and 40 years; A3 = age at diagnosis >40 years; B1 = non-stricturing, non-penetrating disease; B2 = stricturing disease; B3 = penetrating disease

Ref reference, LTA liver test abnormalities, CRP C-reactive protein