Table 2.

Particle size, polydispersity, drug loading and encapsulation efficiency of tacrolimus in different micelles.

Block copolymer	Drug: polymer ratio (w/w)	Drug loading (%)a	Encapsulation efficiency (%)a	Diameter of micelles (nm)b	Polydispersityb
PEO114-b-PCL30	1:10	1.70 ± 0.36	18.62 ± 3.92	41.22 ± 4.83	0.29 ± 0.12
	2:10	1.26 ± 0.28	7.58 ± 1.69	37.15 ± 4.10	0.25 ± 0.07
	3:10	1.28 ± 0.44	5.56 ± 1.89	39.26 ± 2.00	0.31 ± 0.11
PEO114-b-PCL60	1:10	2.17 ± 0.37	27.85 ± 4.45	42.83 ± 1.88	0.14 ± 0.10
	2:10	1.55 ± 0.54	7.25 ± 1.74	40.41 ± 1.88	0.13 ± 0.01
	3:10	1.66 ± 0.41	7.19 ± 1.79	45.19 ± 2.86	0.24 ± 0.08
PEO114-b-PCL120	1:10	2.82 ± 0.12	31.22 ± 1.57	54.73 ± 3.02	0.09 ± 0.05
	2:10	1.92 ± 0.63	11.52 ± 3.80	58.01 ± 3.14	0.12 ± 0.03
	3:10	1.60 ± 0.20	6.94 ± 0.85	58.28 ± 1.14	0.10 ± 0.04
PEO114-b-PCL200	1:10	2.50 ± 0.41	21.41 ± 5.97	86.99 ± 6.00	0.14 ± 0.07
	2:10	1.49 ± 0.29	8.91 ± 1.73	84.41 ± 4.40	0.10 ± 0.02
	3:10	1.75 ± 0.52	7.59 ± 2.24	83.83 ± 1.48	0.11 ± 0.02

Data are presented as mean ± SD (n = 3).

^aThe amount of drug in each formulation was determined by an HPLC assay.

^bAverage diameter (Z_ave) and polydispersity were estimated by the DLS technique.