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. 2017 Feb 9;8(3):685–700. doi: 10.1016/j.stemcr.2017.01.007

Figure 2.

Figure 2

Differentiation Potential of Niche-Derived Cells

(A) EYFP+/GFAP+ astrocytes and EYFP+ neurons (judged by morphology).

(B) EYFP+/O4+ oligodendrocytes near an EYFP+ astrocyte (judged by morphology).

(C) EYFP+/NG2+ OPCs are shown near an EYFP+/βIII-tubulin+ neuron and EYFP+ astrocytes.

(D) An MBP+/EYFP+ cell is shown next to two EYFP+ astrocytes.

(E) After grafting SEZ-derived neurosphere cells in 21 day old mice, EYFP+/MBP+ cells were detected in the CC (three different optical sections of an EYFP+ cell are shown and MBP+ areas of the cell body and of the processes are indicated by white arrowheads).

(F) Co-cultures of neurosphere cells and dorsal root ganglion cells: myelinating oligodendrocytes are generated (white arrows) with strong expression of EYFP in cell bodies.

(G) An EYFP+ myelinating oligodendrocyte is shown in high magnification (the arrowhead indicates the cell body). Note the strong expression of EYFP in the cell body and in some processes and the alignment of MBP+ processes with neurofilament+ axons. Scale bars, 30 μm (A–C, and F); 20 μm (D, E); 10 μm (G).