TABLE 3.
Protein distance analysis on selected antigens between clinical isolates and V160
| Clinical isolate | % Similarity with indicated V160 antigena |
||||||
|---|---|---|---|---|---|---|---|
| gB | gO | gH | gL | pUL128 | pUL130 | pUL131 | |
| VHL/E | 4.1827 | 23.2435 | 3.6864 | 1.9343 | 0.6098 | 1.9075 | 0.0002 |
| VR1814 | 5.1331 | 15.4296 | 0.6727 | 1.9313 | 1.2091 | 2.4834 | 0.0486 |
| VR3908 | 4.1849 | 20.2599 | 3.2649 | 1.9343 | 1.2091 | 2.8977 | 0.0074 |
| VR7863 | 4.1849 | 22.9828 | 3.6831 | 1.5545 | 1.8242 | 1.6592 | 0.0071 |
| VR5235 | 4.1849 | 20.5298 | 2.5922 | 1.5545 | 1.2093 | 2.8766 | 0.0069 |
| VR5022 | 4.2992 | 22.9828 | 3.6831 | 1.5545 | 1.8242 | 0 | 0.0053 |
| UXCA | 4.0721 | 20.3977 | 0.5386 | 0.7754 | 1.8242 | 0.78 | 0.0045 |
| NR | 4.5172 | 28.365 | 3.4305 | 1.9343 | 1.2091 | 3.3916 | 0.7784 |
| TB40E | 4.4039 | 15.4163 | 0.535 | 1.5545 | 1.8242 | 1.6592 | 0.0038 |
| SUB 22 | 4.2992 | 22.9828 | 3.6831 | 1.9343 | 1.8242 | 0 | 0 |
| SUB 24 | 4.2992 | 22.9828 | 3.6831 | 2.3307 | 1.8242 | 0 | 0 |
| Global | 3.520 ± 0.007 | 20.255 ± 0.029 | 2.259 ± 0.006 | 1.582 ± 0.003 | 1.362 ± 0.003 | 1.340 ± 0.005 | 0.205 ± 0.001 |
a
Protein distances were estimated using the algorithm within PhyML using a PAM model of molecular evolution. The values in the table were converted from a distance by taking 1 minus the distance and multiplying it by 100 to arrive at a percent similarity. Global values are the average percentage of similarity among complete viral sequences obtained from NCBI GenBank (n = 194).