Figure 4.

Treatment with SP600125 ameliorated symptoms of nonalcoholic fatty liver disease in HFD-fed rats. The serum levels of (A) ALT, AST, T-CHO and TG; (B) TNF-α; (C) insulin and (D) FFA were determined in HFD-fed rats injected with SP600125 or PBS. Data are presented as the mean ± SD (n=6). *P<0.05, **P<0.01, ***P<0.001. HFD, high-fat diet; ND, normal diet; ALT, alanine aminotransferase; AST, aspartate aminotransferase; T-CHO, total cholesterol; TNF-α, tumor necrosis factor-α; FFA, free fatty acid.