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Berberine inhibits the caspase-1/IL-1β singnaling pathway in tumor-bearing mice. (A-D) The expression level of caspase-1 and IL-1β in the osteosarcoma tissues from tumor-bearing mice. The results were in accordance with the previous outcomes from the Saos-2 and MG-63 osteosarcoma cells. Berberine obviouly reduces the mRNA and the protein level of caspase-1 and IL-1β compared with the control group. *P<0.05 vs. control, **P<0.01 vs. control, #P<0.05 vs. berberine group.
