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. 2017 Jan 2;37(2):684–694. doi: 10.3892/or.2017.5346

Figure 5.

Figure 5.

Spirulina LPS induces limited or does not induce the production of IL-6 and IL-23 in vivo, but augments T cell-dependent IL-12 induction. (A) C3H/HeN and C3H/HeJ mice were injected i.p. with E. coli LPS or Spirulina LPS (200 µg). Serum IL-6, TGF-β, or IL-23 levels were assessed 4 h later. Data represent mean ± SE of 4–5 mice per group. *P<0.05 compared with prior to injection (pre). (B) Whole spleen cells from DO11.10 mice were cultured in the presence of E. coli or Spirulina LPS without OVA for 5 days and B-cell proliferation was estimated. *P<0.05 compared with no LPS. (C) Serum IL-12 levels were measured in tumor-bearing C3H/HeN or C3H/HeJ mice treated as in Fig. 1A. Data represent mean ± SE of 5 mice per group. *P<0.05 compared with saline. (D) Tumor-bearing C3H/HeN mice were treated with Spirulina LPS and with anti-CD4 and/or anti-CD8, or rat IgG antibodies as in Fig. 1B. Serum levels of IL-12 were measured on day 14. *P<0.05 compared with saline.