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. 2016 Oct 26;14(6):5104–5110. doi: 10.3892/mmr.2016.5892

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Copyright: © Wada et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Hierarchical clustering of wt-HER2, delta-HER2 and pSRC, and association with clinicopathological factors. (A) Unsupervised hierarchical clustering of wt-HER2 and delta-HER2 and pSRC separated the breast cancer cases into three major clusters. The levels of (B) wt-HER2 mRNA and (C) delta-HER2 mRNA were significantly higher in clusters 2 and 3 (*P<0.05 vs. cluster 1, **P<0.05 vs. cluster 2). (D) The delta/wt ratio tended to be higher and (E) Ki-67 index tended to be lower in cluster 1, compared with in clusters 2 and 3. HER2, human epidermal growth factor receptor 2; pSRC, phosphorylated-SRC; wt, wild type.