Figure 2.

DAPT Treatment Induces Genetic Programs Related to Muscle Development, Differentiation, and Excitation-Contraction Coupling

RNA-seq was performed on MEFs infected with GHMT and treated for 15 days with DMSO (vehicle) or DAPT.

(A) Heatmap generated with differentially expressed genes.

(B) Graphical representation of gene ontology analysis using PANTHER Overrepresentation Test.

(C) Hierarchical clustering and heatmap using cardiomyocyte- and fibroblast-specific genes.

(D) Enrichment plots of the indicated gene sets and their nominal p values. See also Figure S4 and Tables S2–S4.