Figure 1.

VEGF inhibition improved neurobehavioral recovery in ischemic rats. Functional recovery was evaluated using (A) neurological score, (B) the elevated body swing test and (C) the rotarod test. The elevated body swing test and the rotarod test were performed prior to MCAO and at 24 h following MCAO. RB-222 treatment at a dose of 10 µg significantly improved neurobehavioral outcomes at 24 h after MCAO. Data are presented as the mean ± standard deviation (n=6). ^#P<0.05 vs. Sham; *P<0.05 vs. MCAO or IgG; ^&P<0.05 vs. RB-222 (5 µg). VEGF, vascular endothelial growth factor; MCAO, middle cerebral artery occlusion.