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Difference in BMP-2 responsiveness in the hOSCC cell lines. Expression of BMP-2 target genes Smad6, Smad7 and ID1 was evaluated in (A) HSC-4, (B) HSC-3, (C) HSC-2 and (D) SAS hOSCC cell lines following treatment with 10 ng/ml BMP-2 for 3 h (light gray bars) vs. untreated controls (dark gray bars). Data represent the mean ± SD from triplicate experiments (**P<0.01). hOSCC, human oral squamous cell carcinoma; BMP, bone morphogenetic protein.
